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| Receptor endocytosis ： ウィキペディア英語版 |
Receptor-mediated endocytosis
Receptor-mediated endocytosis (RME), also called clathrin-dependent endocytosis, is a process by which cells absorb metabolites, hormones, other proteins - and in some cases viruses - (endocytosis) by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecules being absorbed. Hence, it is also called absorptive pinocytosis .
==Process==
After the binding of a ligand to plasma membrane-spanning receptors, a signal is sent through the membrane, leading to membrane coating, and formation of a membrane invagination. The receptor and its ligand are then opsonized in clathrin-coated vesicles. Once opsonized, the clathrin-coated vesicle uncoats (a pre-requisite for the vesicle to fuse with other membranes) and individual vesicles fuse to form the early endosome. Since the receptor is internalized with the ligand, the system is saturable and uptake will decline until receptors are recycled to the surface.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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